John SantaLucia Jr. BIOCHEMISTRY/PHYSICAL/THEORETICAL/COMPUTATIONAL CHEMISTRY DNA, RNA Folding and Function (Biochemistry & Physical) Professor Dept. of Chemistry Wayne State University Phone: (313) 577-0101 email: jsl@chem.wayne.edu There are three major research projects in our laboratory: 1) 3D structure prediction and analysis of RNA and DNA, 2) NMR structure determination of RNA with bound drugs and proteins and 3) Nucleic acid-based nanotechnology. Figure Caption: Results of homology modeling of the “adenine dependent riboswitch”. The structure in green is the crystal structure 1Y26.pdb and the structure colored by atom is the predicted homology model derived from 1Y27.pdb. The RMSD of the prediction is 1.24 Å (J. SantaLucia, unpublished results). If the below 'MDL Chime' image is not displayed properly download the 'MDL Chime' plugin from MDL's website. Figure Caption: NMR STRUCTURE OF THE 690 LOOP OF 16 S rRNA OF E. coli >> Click here for more structures

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